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Equipment: Standard equipment for research in biochemistry and molecular biology is maintained at each participating campus. In addition, central facilities exist at several campuses for molecular biology and physical biochemistry. These facilities include instrumentation and support services for DNA synthesis, peptide synthesis, peptide sequencing and electron microscopy. Other specialized research equipment includes HPLC systems, high-field NMR spectrometers, (500 and 600 MHz), X-ray diffractometers, EPR spectrometers, laser-based lifetime and steady-state fluorometers, and mass spectrometers.

CUNY is one of the institutional members of the New York Structural Biology Center (NYSBC). This Center, located adjacent to City College, houses the largest and most advanced cluster of high-field research magnets (NMR equipment) in the United States.

Students and faculty have free access to two Linux run computer clusters (instructional and research) at the Graduate Center and to many computational facilities at the senior colleges.

Library Facilities: Each senior college maintains a library with a wide selection of scientific journals, with access for CUNY faculty and students to many online journals. In addition, The Mina Rees Library is an integral and vital part of The Graduate Center. The Science, Industry, and Business Library (SIBL) of the New York Public Library is also located within the same building as the Graduate Center. The SIBL research collection comprises 1.5 million volumes.