Areas of Expertise:
While DNA is the blueprint for the cell, it is the proteins that do the bulk of the work. About 30% of proteins require metal ions for proper function and their dysfunction leads to human disease. The Gibney Lab takes a constructive approach toward understanding metalloprotein structure-function relationships. Using inorganic chemistry and protein biophysics, his lab designs and synthesizes simplified metalloproteins (maquettes) to test the fundamental tenets of metalloprotein engineering.
Aussignargues, C.; Pandelia, M.-E.; Sutter, M.; Plegaria, J.S.; Zarzycki, J.; Turmo, A.; Huang, J.; Ducat, D.C.; Hegg, E.L.; Gibney, B.R.; Kerfeld, C.A. "Structure and Function of a Baterial Microcompartment Shell Protein Engineered to bind a [4Fe-4S] Cluster", J. Am. Chem. Soc. 2016, 138, 5262-5270.
Reddi, A.R.; Pawlowska, M.; Gibney, B.R.; "Evaluation of the Intrinsic Zn(II) Affinity of a Cys3His1 Site in the Absence of Protein Folding Effects", Inorg. Chem., 2015, 54, 5942-5948.
Chan, K.L.; Bakman, I.; Marts, A.R.; Batir, Y.; Dowd. T.L.; Tierney, D.L.; Gibney, B.R.; "Characterization of the Zn(II) Binding Properties of the Wilms’ Tumor Suppressor Protein C-terminal Zinc Finger Peptide", Inorg. Chem., 2014, 53, 6309-6320.
Gibney, B.R. "Heme" Encyclopedia of Biophysics, Gordon Roberts, Ed. Springer, 2013.