Areas of Expertise:
While DNA is the blueprint for the cell, it is the proteins that do the bulk of the work. About 30% of proteins require metal ions for proper function and their dysfunction leads to human disease. The Gibney Lab takes a constructive approach toward understanding metalloprotein structure-function relationships. Using inorganic chemistry and protein biophysics, his lab designs and synthesizes simplified metalloproteins (maquettes) to test the fundamental tenets of metalloprotein engineering.
"Heme" entry in Encyclopedia of Biophysics, Gordon Roberts, Ed., Springer. (Books and Publications: Other Article) 2013
"Metallopeptides as Tools to Understand Metalloprotein Folding and Stability." Protein Folding and Metal Ions -- Mechanisms, Biology and Disease. Eds. C.M. Gomes and P. Wittung-Stafshede. New York: CRC Press. 227-45. (Books and Publications: Chapter) 2011
Deng, B., S. Parthasarathy, W. Wang, B.R. Gibney, K.P. Battaile, S. Lovell, D.R. Benson and H. Zhu. "Unique Heme Pocket in Human Ncb5or and Structural Basis for Intra-Domain Electron Transfer., Journal of Biological Chemistry 285: 30181-91. (Books and Publications: Peer Reviewed Article) 2010
Reedy, C.J., M.M. Elvekrog and B.R. Gibney. "Development and Analysis of a Heme Protein Structure-Electrochemical Function Database." Nucleic Acids Research 36: D307-13. (Books and Publications: Peer Reviewed Article) 2008