Prof. Lakshman's research is in organic chemical synthesis pertaining to questions of biological interest. The program has many facets but can be broadly divided into the following areas.
A. Nucleoside Modifications. Here new metal-catalyzed as well as uncatalyzed routes are being invented, to enable nucleoside modification.
B. Studies on Environmental Pollutants. In this area, structural and biological effects of DNA modification by environmental pollutants are studied. In addition, new chemical methodology to create model systems for studying metabolic activation processes of environmental pollutants are being developed.
C. New Chemical Methodology. New methods to create molecules, and new physiologically important molecules are developed, via new approaches.
Research is conducted with the idea that Fundamental Understanding drives New Chemistry (FUNCy). Thus, development of chemical methodology and synthesis of novel molecules require a sound understanding of mechanistic organic chemistry, as being integral to the research.
Representative Recent Publications
Gurram, V.; Pottabathini, N.; Garlapati, R.; Chaudhary, A. B.; Patro, B.; Lakshman, M. K.: C-C cross-coupling reactions of O6-alkyl-2-haloinosine derivatives and a one-pot cross-coupling/O6-deprotection procedure, Chemistry-An Asian Journal, 2012, 7, in press.
Kokatla, H. P.; Lakshman, M. K: Two-step, one-pot synthesis of inosine, guanosine, and 2'-deoxyguanosine O6-ethers, Current Protocols in Nucleic Acid Chemistry (John Wiley and Sons, Inc.) 2012, in press.
Lakshman, M. K.; Deb, A.; Chamala, R. R.; Pradhan, P.; Pratap, R.: Direct arylation of 6-phenylpurine and 6-arylpurine nucleosides by ruthenium-catalyzed C-H bond activation, Angewandte Chemie, International Edition 2011, 50, 11400-11404. DOI: 10.1002/anie.201104035
Featured on the inside cover-
Kokatla, H. P.; Thomson, P. F.; Bae, S.; Facile reduction of amine N-oxides by diboron compounds, Journal of Organic Chemistry 2011, 76, 7842-7848. DOI: 10.1021/jo201192c