Areas of Expertise:
Professor Murelli's lab is interested in developing and using the tools of chemistry and biology to meet current challenges in medicine. A major driving force behind the lab's work is the development of new synthetic methods that enable rapid access to known but underexplored small molecules. These routes are then applied to studying and understanding the target's function, and developing improved analogs that could serve as therapeutics.
Meck, C., N. Mohd and R.P. Murelli. "An oxidopyrylium cyclization/ring-opening route to polysubstituted alpha‑hydroxytropolones." Organic Letters 14: 5988-91. (Books and Publications: Forthcoming Publications) 2012
Munoz, A. and R.P. Murelli. "Acid-mediated coupling of gamma-hydroxybutenolides and aldehydes: Synthesis of a new class of spirocyclic ketal-lactones." Tetrahedron Letters 53: 6779-81. (Books and Publications: Peer Reviewed Article) 2012
Nelson, J.W., A.G. Chamessian, P.J. McEnany, R.P. Murelli, B.I. Kazmiercak and D.A. Spiegel. "A Biosynthetic Strategy for Re-engineering the Staphylococcus Aureus Cell Wall With Non-native Small Molecules." ACS Chemical Biology 5: 1147-55. (Books and Publications: Peer Reviewed Article) 2010
Zhang, A.X., R.P. Murelli, C. Barinka, J. Michel, A. Cocleaza, W.L. Jorgensen, J. Lubkowski and D.A. Spiegel. "A Remote Arene Binding Site of Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules." Journal of the American Chemical Society 132: 12711-16. (Books and Publications: Peer Reviewed Article) 2010