Professor Lazaridis 's research is in the area of Theoretical and Computational Biophysical Chemistry, which aims to understand how biological systems work in terms of the fundamental laws of Physics and Chemistry. Biomolecules, such as proteins and nucleic acids, have well defined conformations which often change in the course of their function. Our goal is to understand the forces that operate within and between biomolecules and develop quantitative mathematical models for their energy as a function of conformation.
Mihajlovic, M., Lazaridis, T. "Charge Distribution and Imperfect Amphipathicity Affect Pore Formation by Antimicrobial Peptides", BBA-Biomembranes , in press (2012)
Lazaridis, T. "Ligand and Receptor Conformational Energies, in Protein-ligand interactions (Gohlke, H., Ed.), in press (2012)
Li, Z., Lazaridis, T. "Computing the thermodynamic contributions of interfacial water", Methods in Molecular Biology, 819:393-404 (2012)
Zhan H., Lazaridis, T. "Influence of the membrane dipole potential on peptide binding to lipid bilayers", Biophys Chem, 161:1-7 (2012)