The primary research focus of my lab is on understanding and treating late-life depression, with a particular emphasis on a subtype of depression called vascular depression. In particular, we have been focusing on developing a psychometric framework for evaluating diagnostic entities in order to develop empirically-based diagnostic criteria for the disorder. As part of this effort, we are conducting an 8-week clinical trial examining the neurocognitive and neuroimaging (MRI) mediators of antidepressant treatment response (i.e., Lexapro) in patients with and without vascular depression. This study is being conducted in collaboration with the Mid and Late-Life Depression Research Clinic at Columbia University and the New York State Psychiatric Institute, as well as in the Outpatient Psychiatry and Geropsychiatry Services at Harlem Hospital. We are also interested in the role of executive dysfunction plays in late-life depression. We are extending this research in order to characterize the course of vascular depression and its relationship to other late-life psychiatric disorders such as dementia. We are also interested in understanding the nature of the executive functions, the role executive dysfunction plays in late-life depression and its relationship to dementia, and the impact of executive dysfunction on antidepressant treatment response in depressed older adults.