Daniel Keedy i
s an Assistant Professor who joined the Structural Biology Initiative of the CUNY Advanced Science Research Center in January 2018. He is also an Assistant Professor of Chemistry & Biochemistry at The City College of New York, and is a faculty member of the CUNY Graduate Center’s PhD Programs in Biochemistry and in Chemistry. Before joining CUNY, Daniel was an AP Giannini Postdoctoral Fellow in Bioengineering and Therapeutic Sciences at the University of California, San Francisco working with Professor James Fraser. He earned his PhD in Biochemistry and Structural Biology & Biophysics from Duke University working with Jane and David Richardson, after receiving his BA in Biochemistry & Molecular Biology from Rhodes College.
Research in the Keedy Lab is focused on the interplay between protein sequence, conformational heterogeneity, and biological function. The research aims to characterize the ensemble of structures adopted by globular proteins, and to address how it depends upon amino acid sequence, protein-protein interactions, and the binding of allosteric modulators.
The methods used in the Keedy research lab include variable temperature X-ray crystallography and the application of multi-dataset three-dimensional modeling algorithms. The unique combination of computational and experimental biophysics approaches allows Daniel and his research group members to address fundamental questions in structural biology. For example, how do the amino acid sequences of proteins fine-tune conformational flexibility to modulate function? Can lessons from natural proteins be used to design new proteins with orthogonal functions for basic research or biomedicine? Special attention is being devoted to learning how conformational changes observed at different temperatures alter the structure and function of enzymes such as Protein Tyrosine Phosphatases, which are viewed as promising therapeutic targets in diseases such as diabetes.
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