Elevated Phospholipase D Activity in Androgen-Insensitive Prostate Cancer Cells Promotes Both Survival and Metastatic Phenotypes
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- Elevated Phospholipase D Activity in Androgen-Insensitive Prostate Cancer Cells Promotes Both Surviv
Prostate cells are hormonally driven to grow and divide. Typical treatments for prostate cancer involve blocking activation of the androgen receptor by androgens. Androgen deprivation therapy can lead to the selection of cancer cells that grow and divide independently of androgen receptor activation. Prostate cancer cells that are insensitive to androgens commonly display metastatic phenotypes and reduced long-term survival of patients.
Submitted on: MAR 16, 2018
Category: Biochemistry | Biology | GC Press Coverage