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Susan Rotenberg
Position: Professor
Campus Affiliation: Queens College
Phone: 718-997-4133
Degrees/Diplomas: Ph.D., Brown University
Research Interests: Biochemistry and Molecular Biophysics
Protein kinase C (PKC) is a Ca2+ and phospholipid-dependent protein kinase that is a vital component in various signaling pathways that govern proliferation, differentiation, and cell movement. In malignant cells, PKC promotes unregulated cellular growth and metastasis, as evidenced by 1) its role as the cellular receptor for tumor promoters, 2) its elevated levels of expression in certain tumors, and 3) disturbances in proliferation, migration, and reduction-oxidation processes of cells genetically engineered to overproduce PKC.