Professor Lazaridis 's research is in the area of Theoretical and Computational Biophysical Chemistry, which aims to understand how biological systems work in terms of the fundamental laws of Physics and Chemistry. Biomolecules, such as proteins and nucleic acids, have well defined conformations which often change in the course of their function. Our goal is to understand the forces that operate within and between biomolecules and develop quantitative mathematical models for their energy as a function of conformation.
Lipkin R., Lazaridis T. "Computational studies of peptide-induced membrane pore formation", Phil. Trans. R. Soc. B, 372:20160219 (2017)
Pino-Angeles A.,Leveritt J.M. III, Lazaridis T. "Pore Structure and Synergy in Antimicrobial Peptides of the Magainin Family", PLOS Comp. Biol. 12:e1004570 (2016)
Versace R., Lazaridis T. "Modeling Protein-Micelle Systems in Implicit Water", J. Phys. Chem. B, 119:8037-47 (2015)
Leveritt J.M. III, Pino-Angeles A., Lazaridis T. "The Structure of a Melittin-Stabilized Pore", Biophys J, 108:2424-6 (2015)