Dr. Brumberg's research is characterized by the integration of anatomical and physiological techniques to further our understanding of the individual building blocks of cortical microcircuit and the role that sensory activity has on their development. Using the rodent sensorimotor cortex as a model system the Brumberg lab demonstrated that following sensory deprivation (via whisker trimming) there is a dramatic reduction in the extracellular matrix surrounding a specific class of GABAergic neurons. His more recent studies have focused on how sensory deprivation influences structural changes in the brain by analyzing dendritic architectures', spine densities s as well as the impact on glial cells. In parallel, Dr. Brumberg has also investigated how information is relayed in the brain between distinct functional areas. His results have shown that neurons participating in specific pathways (eg. callosal versus cortico-thalamic) have specific anatomical, physiological and synaptic characteristics which are likely adapted to their roles in inter-areal communication within the brain.
The focus of the Brumberg’s lab research is to characterize the neurons of the mouse barrel cortex with an emphasis on the interactions between the sensory and motor systems that govern the animals whisking behavior.