Daniel Keedy

Professor Keedy develops experimental and computational methods to control proteins by biasing toward specific conformations that underlie functions such as allostery, ligand binding, and catalysis. His work reveals new opportunities to modulate the activities of therapeutic targets such as tyrosine phosphatases with small molecules and protein engineering, and also offers insights into more general evolutionary processes that led to functional diversity in the human genome.

Prior to his appointment, Daniel Keedy, Ph.D. was an AP Giannini Postdoctoral Fellow in Bioengineering and Therapeutic Sciences at the University of California, San Francisco working with Professor James Fraser. He earned his PhD in Biochemistry and Structural Biology & Biophysics from Duke University working with Jane and David Richardson, after receiving his BA in Biochemistry & Molecular Biology from Rhodes College. His research on protein structural flexibility, temperature-dependent X-ray crystallography, and allosteric regulation has led to over 15 publications in leading scientific journals and over ten presentations at a variety of scientific meetings.

Keedy was appointed to the ASRC in January 2018.

About the Keedy Lab

The Keedy Lab combines computation and experiments to reveal alternative protein conformations and explore how they underlie dynamic functions such as catalysis, ligand binding, and allosteric regulation.

Publications

View publications at https://keedylab.org/publications/

Awards and Grants

• Cottrell Scholar Award 7/2022-6/2025
  “Illuminating structural motions that underlie allostery in dynamic phosphatase enzymes”
  $100,000 total costs ($100,000 direct)
• NIH R35GM133769 9/2019-8/2024
  “Mapping and Exploiting the Internal Wiring of Dynamic Protein Structures”
  $1,944,246 total costs ($1,250,000 direct)
• NIH R35GM133769-03S1 9/2021-8/2022
  Administrative Equipment Supplement: Nanuq Cryocooling System
  $188,000 total costs ($188,000 direct)